4-Methoxyphenylboronic acid, also known as p-methoxyphenylboronic acid, is an organoboron compound used as a coupling partner in organic synthesis. Identified by CAS 5720-07-0, it contains a methoxy-substituted phenyl group bonded to a boronic acid group; its molecular formula is C7H9BO3 and its molar mass is 151.96 g/mol. Its most recognized application is Suzuki–Miyaura coupling, where it can transfer the 4-methoxyphenyl group to a suitable organic electrophile, commonly an aryl halide. For buyers, the key considerations are not only identity and purity, but also batch documentation, packaging, and suitability for the intended reaction conditions.
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The compound consists of a phenyl ring bearing a methoxy group at the 4-position and a boronic acid group attached to the ring. The “4” or “para” designation means the methoxy substituent and boronic acid group occupy opposite positions on the aromatic ring. This substitution pattern gives chemists a defined building block for introducing a 4-methoxyphenyl unit into a target molecule.
Its chemical identity is distinct from that of other methoxyphenylboronic acid isomers, including the 2-methoxy and 3-methoxy forms. Those compounds have the same molecular formula but different substituent positions, which can affect the structures and properties of the products made from them. When requesting a quote or reviewing a specification, use both the full chemical name and CAS 5720-07-0 to reduce the risk of an isomer mix-up.
The boronic acid group is the reactive functionality used in many cross-coupling applications. Under suitable catalytic and basic conditions, it can participate in a reaction with an organic electrophile and contribute its attached aryl group to a new carbon–carbon bond. The methoxy substituent remains part of the aryl unit and may be retained in the coupled product for further synthesis or as a structural feature.
Like other boronic acids, this compound’s behavior can depend on solvent, water content, pH, temperature, and storage conditions. Product handling guidance should therefore be taken from the supplier’s current safety data sheet and product documentation rather than inferred from the chemical name alone. Physical appearance, assay, impurity limits, and recommended storage should likewise be confirmed against the specific lot’s documentation.
A product listing identifies the general chemical, but a buyer’s decision should be based on a lot-specific specification and certificate of analysis where available. These documents can help confirm the reported identity and assay, as well as any additional parameters agreed for the order. Do not assume that a particular purity, test method, or packaging format applies unless it is stated in the supplier’s offer.
| Item to review | Buyer consideration |
|---|---|
| Identity | Confirm the chemical name, CAS 5720-07-0, and para substitution pattern. |
| Assay and impurities | Compare the proposed specification with the needs of the synthesis or process. |
| Documentation | Request applicable analytical and safety documents for the offered material. |
| Supply details | Confirm pack size, availability, lead time, and shipping arrangements before ordering. |
Suzuki–Miyaura coupling joins an organoboron reagent with an organic electrophile, often an aryl or heteroaryl halide, using a palladium catalyst and a base. In a suitable reaction system, 4-methoxyphenylboronic acid supplies the 4-methoxyphenyl fragment, producing a coupled product with a new carbon–carbon bond. The method is widely used in organic synthesis because it offers a route to biaryl and related structures, although the outcome depends on the particular substrates and conditions.
Researchers may consider this reagent when designing substituted biaryls, preparing intermediates for further functionalization, or exploring structure–activity relationships in research programs. The methoxy group provides a defined substituent on the product and may be retained or modified in subsequent steps. The compound is a building block, not a guarantee of a particular yield or reaction outcome.
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There is no universally correct recipe for every coupling involving this boronic acid. Catalyst and ligand selection, the identity of the electrophile, base, solvent, concentration, and reaction temperature can all influence conversion and selectivity. As an initial screening framework—not a product specification or guaranteed procedure—chemists may evaluate 1.0–1.5 molar equivalents of boronic acid and temperatures in a broad range of 20–100 °C.
Other variables may also be screened according to the substrate and laboratory’s established methods. For example, catalyst loading in the approximate range of 0.1–2 mol% palladium is sometimes considered during reaction development, but the appropriate amount can be outside that range for a particular system. Any proposed conditions should be checked against relevant literature, internal procedures, and appropriate safety controls before use.
For this product, “options” generally refer to commercial and specification choices rather than different chemical structures. Depending on the supplier’s offering, buyers may be able to discuss research-scale or larger quantities, requested assay limits, packaging, and documentation. Availability of a specific grade or configuration must be confirmed for the requested order rather than presumed.
Some projects may compare boronic acids with alternative organoboron reagents, such as boronate esters, or consider a different coupling partner. These alternatives are not automatically interchangeable: stability, solubility, activation behavior, and compatibility with the chosen reaction system can differ. The best choice depends on the synthetic objective and should be evaluated at the reaction level.
For procurement, start by sharing the exact identifier, required quantity, intended use, and any specification requirements. Ask the supplier to confirm the offered assay, available lot documentation, packaging, lead time, and shipping terms in writing. If your process has a critical impurity limit or analytical method, include it in the inquiry so feasibility can be checked before an order is placed.
Maison Chemical supports B2B inquiries for 4-Methoxyphenylboronic acid CAS 5720-07-0. We can discuss the requested quantity, specification expectations, documentation, and delivery requirements as part of a quotation review. Availability, commercial terms, and any product-specific details should be confirmed for each inquiry.
4-Methoxyphenylboronic acid CAS 5720-07-0 is a para-methoxy-substituted arylboronic acid used primarily as a coupling partner in Suzuki–Miyaura synthesis. Its value is the ability to introduce a defined 4-methoxyphenyl group into suitable products, while actual reaction performance depends on the substrates and chosen conditions. For a purchasing decision, verify the exact identity, lot specification, documentation, quantity, and delivery terms rather than relying on a generic product description.
To request a quotation from Maison Chemical, provide your required quantity, target specification, destination, and any documentation needs. This information helps us review the supply requirements and confirm the details relevant to your project.
Contact us to discuss your requirements of 4-Methoxyphenylboronic acid CAS 5720-07-0. Our experienced sales team can help you identify the options that best suit your needs.